Transitional cell metaplasia may affect the cervical mucosa more frequently in menopausal women and may be associated with an epithelial atrophy.
Histologically, it appears like a hyperplastic urothelium with underlying layers made of basal and parabasal cells resembling transitional epithelial cells. Their vertical and oval-shaped nuclei show longitudinal grooves. Superficial cell layers are more horizontal but never adopt a typical morphology of umbrella cells.
Cytologically, these cells form clusters.
This lesion may be confused with a CIN 3.
Histopathology atlas Cytopathology atlas