Glossary Definitions

Filter by language: English / Français / Portugues / 中文

CIN 3
Cervical intraepithelial neoplasia grade 3 (Richart) is a preneoplastic lesion of squamous epithelium corresponding to previous severe dysplasia and squamous intraepithelial carcinoma.
Histologically, the proliferation of atypical parabasal cells, oriented in a vertical fashion, involves more than two-thirds. Architectural disorganization, typical or atypical mitotic figures, cytonuclear criteria of malignancy are present in more than the lower two thirds. Keratinization may be present, at the surface or in isolated cells inside the epithelium. Koilocytosis may be observed.

Histopathology atlas

IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France - Tel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75
© IARC 2023 - Terms of use - Privacy Policy.