Glossary Definitions

Filter by language: English / Français / Portugues / 中文

CIN 2
Cervical intraepithelial neoplasia grade 2 (Richart) is a preneoplastic lesion of squamous epithelium which corresponds to previous moderate dysplasia.
Histologically, basal cell hyperplasia extends from the basement membrane to the middle third of the squamous epithelium. The cell differentiation does not proceed above the parabasal or deep intermediate cell. Nuclear abnormalities and cytoplasmic maturation anomalies are present. Mitoses are visible in the lower two thirds.
Keratinization may be present, at the surface or in isolated cells inside the epithelium. Koilocytosis is frequently observed.

Histopathology atlas

IARC, 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France - Tel: +33 (0)4 72 73 84 85 - Fax: +33 (0)4 72 73 85 75
© IARC 2023 - Terms of use - Privacy Policy.