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Lipoma is a benign slow-growing tumour of adipose tissue. They are most often seen in the buccal mucosa followed by the tongue and floor of mouth. They are more often seen after the age of 40 years, with no gender predilection. Clinically, they appear as diffuse thickening, or as a semi-fluctuant mass, with normal overlying mucosa. Malignant transformation is extremely rare. The diagnosis is confirmed by histopathological examination. Surgical excision is the treatment of choice.

Differential diagnosis:

Figure 1: Lipoma of the floor of the mouth. Note the smooth, yellowish swelling in the anterior part of the floor of mouth, near the lingual frenum.
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