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Research projects

Colorectal cancer

Study sites: Lampang Province, Thailand
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:Thiravud Khuhaprema, Pattarawin Attasara, Suleeporn Sangrajrang, Petcharin Srivatanakul, National Cancer Institute, Bangkok, Thailand
Start date: 2010
Closure date:Ongoing
  • To evaluate the impact of faecal occult blood test (FOBT) screening once in 5 years on colorectal cancer (CRC) incidence and mortality in the province following the implementation of the pilot project
  • To facilitate a health economics evaluation of CRC screening in Thailand by providing real population-based information on various study parameters (e.g. performance of screening and triage tests), costs, and effectiveness of the study procedures
  • To describe the context, processes, and mechanisms of integrating CRC screening project elements into the existing organizational and management structures within the Thai health-care services
  • To assess the impact of workload on primary and secondary care services in the province due to this demonstration project
  • To address the determinants of population participation in screening, triage, and treatment
  • To measure the acceptability to users and health service providers and address the influence of sociodemographic and psychosocial variables on participation (uptake) in screening, diagnosis, and treatment
Study outcomes: The study demonstrated that screening for colorectal cancer was feasible in a primary care setting in a middle-income country. The Thai government is considering scaling up the programme and implementing it in other provinces.
Publications: Khuhaprema T., Sangrajrang S., Lalitwongsa S., Chokvanitphong V., Raunroadroong T., Ratanachu-Ek T., Muwonge R., Lucas E., Wild C., Sankaranarayanan R. Organised colorectal cancer screening in Lampang Province, Thailand: preliminary results from a pilot implementation programme. BMJ Open. 2014;4(1):e003671.
PMID: 24435889
Funding: Ministry of Public Health, Thailand, through the National Cancer Institute (NCI), Bangkok, Thailand
Study sites:
  • Centre for Epidemiology and Prevention in Oncology (CPO), Italy
  • Cancer Society of Finland (CSF), Mass Screening Registry, Finland
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:
  • Antonio Ponti, Carlo Senore, Guglielmo Ronco, Nereo Segnan, CPO, Italy
  • Ahti Antilla, CSF, Mass Screening Registry, Finland
  • Representatives from EU Member States: Austria, Belgium, Bulgaria, Croatia, Cyprus, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom
Start date: 2015
Closure date:2017
  • To update and expand the scope of the first report
  • To report the updated status and organization of the population-based breast, cervical, and colorectal cancer screening programmes in the 28 EU Member States
  • To estimate selected indicators on programme performance included in the EU quality assurance guidelines for breast, cervical, and colorectal cancer screening
  • More than 100 experts from the 28 Member States contributed to the preparation of the report.
  • Qualitative data (nature and organization of the programme, protocol of screening and diagnosis, mode of invitation and recall, quality assurance practices, etc.) were collected through online questionnaires completed by the country data providers. The data providers were requested to provide the most up-to-date information as of July 2016.
  • Performance data (screening rate, coverage by invitation/examination, participation rate, and other indicators) were collected for the index year 2013 for countries having population-based programmes using structured data tables. The completeness of data collection across the screening and diagnosis processes was estimated.
  • Analysed data and the draft report were shared with the data providers and the scientific committee for review and validation.
Publications: View the report
Funding: The European Union Public Health Programme (scientific and technical support to the European Partnership for Action Against Cancer)
Study sites: Rabat, Morocco
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:Laila Amrani, Basma El Khannoussi, National Oncology Institute, Rabat, Morocco
Start date: 2017
Closure date:Ongoing
Objectives: To evaluate the acceptability, feasibility, organization, implementation, monitoring, and evaluation of colorectal cancer (CRC) screening in the general population setting in Morocco by integrating the programme within the existing public health services to inform and guide the eventual scaling up of CRC screening to cover the entire country
Methodology:A cross-sectional study will be conducted between November 2017 and February 2019. The study is a population-based pilot demonstration project of CRC screening using immunochemical faecal occult blood testing (iFOBT), targeting eligible men and women residing in the geographical region covered by selected primary health centres in the Rabat region of Morocco. The study will be widely publicized in the region to inform and encourage eligible men and women to voluntarily participate, adhere to the protocol, and benefit from the programme by reducing their risk of developing CRC.
Funding: Lalla Salma Foundation for Cancer Prevention and Treatment

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