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Cancer control



Study sites: Morocco: Casablanca, Fez, Rabat
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:
  • Professor El Rhazi, Institut de Recherche sur le Cancer, Fez
  • Dr Bendahhou, Centre Mohammed VI pour le traitement des cancers, Casablanca
  • Professor Errihani, Medical School, Mohammed V University, Rabat
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Start date: 2016
Closure date:Ongoing
Objectives:
  • To develop protocol for quality assurance of the national breast and cervical cancer screening programme of Morocco using standardized methodology and tools
  • To evaluate the performance of the programme by calculating some of the process and outcome indicators and comparing them with established standards
  • To prepare a quality improvement plan in consultation with the national stakeholders
  • To deliver the quality assurance protocol and the tools to the programme focal points to be incorporated into the programme
Methodology:The evaluation will be based on information obtained through in-depth interviews of the key functionaries of the programme, focus group discussions with various categories of service providers, and supervisory visits to randomly selected facilities offering screening and diagnostic services.
Funding: Lalla Salma Foundation for Cancer Prevention and Treatment
Study sites: imPACT Reviews have been carried out in: Algeria (2015), Bangladesh (2013), Benin (2013), Bosnia and Herzegovina (2015), Botswana (2013), Burundi (2017), Cambodia (2013), Croatia (2014), Fiji (2014), Georgia (2014), Kyrgyzstan (2015), Lebanon (2013), Madagascar (2015), Malaysia (2013), Mauritania (2012), Mongolia (2011), Myanmar (2015), Nepal (2012), Pakistan (2013), Rwanda (2014), Tunisia (2013), Viet Nam (2015)
PIs from collaborating institutions:The International Atomic Energy Agency (IAEA), WHO, IARC
Map:
Start date: 2011
Closure date:Ongoing
Objectives:
  • To carry out a comprehensive assessment of the country’s cancer control capacity in the areas of cancer control planning, cancer information, prevention, early detection, diagnosis and treatment, palliative care, training, and civil society activities
  • To carry out a capacity and needs assessment for the effective implementation of the country’s radiation medicine programme as a component of a comprehensive national cancer control programme (NCCP)
  • To explore suitable project proposals and potential sources of funding for cancer control interventions
Methodology:Assessment is carried out through meetings with the focal point at the Ministry of Health, field visits at the three levels of care, discussions with health-care providers, and interaction with the local officers of the various health-related UN agencies (mainly WHO) and IAEA country offices.
Funding: International Atomic Energy Agency (IAEA) Programme of Action for Cancer Therapy (PACT)
Study sites: Dhaka, Bangladesh
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:Dr Ashrafun Nessa, Bangabandhu Sheikh Mujib Medical University (BSMMU)
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Start date: 2006
Closure date:Ongoing
Objectives: To provide technical support to help organize a screening programme for cervical cancer prevention in Bangladesh
Methodology:The following technical support is provided:
  • Training of health providers on visual inspection with acetic acid (VIA), colposcopy, and thermocoagulation
  • Guidance for the local team on the organization of the screening programme and services
  • Evaluation of the programme by estimation of the cervical early detection process measures
Publications: Nessa A., Hussain M.A., Rahman J.N., Rashid M.H., Muwonge R., Sankaranarayanan R. Screening for cervical neoplasia in Bangladesh using visual inspection with acetic acid. Int J Gynaecol Obstet. 2010;111(2):115-8.
PMID: 20674919
Sankaranarayanan R., Bhatla N., Gravitt P.E., Basu P., Esmy P.O., Ashrafunnessa K.S., Ariyaratne Y., Shah A., Nene B.M. Human papillomavirus infection and cervical cancer prevention in India, Bangladesh, Sri Lanka and Nepal. Vaccine. 2008;26(Suppl 12):M43-M52.
PMID: 18945413
Study sites: National Cancer Institute / National Cancer Control Programme, Sri Lanka
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:Suraj Perera
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Start date: 2006
Closure date:Ongoing
Objectives: To provide technical support to the national cancer control programme
Methodology:The following technical support is provided:
  • Training of health providers
  • Guidance for the local team on the organization of the screening programme and services
  • Evaluation of the programme
Publications: Sankaranarayanan R., Bhatla N., Gravitt P.E., Basu P., Esmy P.O., Ashrafunnessa K.S., Ariyaratne Y., Shah A., Nene B.M. Human papillomavirus infection and cervical cancer prevention in India, Bangladesh, Sri Lanka and Nepal. Vaccine. 2008;26(Suppl 12):M43-M52.
PMID: 18945413
Study sites: Thailand
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:Weerawut Imsamran, Suleeporn Sangrajrang, Pattarawin Attasara, National Cancer Institute, Bangkok, Thailand
Map:
Start date: 2006
Closure date:Ongoing
Objectives: To provide technical support to the national cancer control programme
Methodology:The following technical support is provided:
  • Training of health providers (monitoring and evaluation)
  • Guidance for the local team on the organization of the screening programme and services
  • Evaluation of the programme (cytology programme and quality assurance)
Publications: Deerasamee S., Srivatanakul P., Sriplung H., Nilvachararung S., Tansuwan U., Pitakpraiwan P., Kaewkungwal J., Singhasivanon P., Nimnakorn P., Sankaranarayanan R. Monitoring and evaluation of a model demonstration project for the control of cervical cancer in Nakhon Phanom province, Thailand. Asian Pac J Cancer Prev. 2007 Oct-Dec;8(4):547-56.
PMID: 18260727
Khuhaprema T., Attasara P., Srivatanakul P., Sangrajrang S., Muwonge R., Sauvaget C., Sankaranarayanan R. Organization and evolution of organized cervical cytology screening in Thailand. Int J Gynaecol Obstet. 2012;118(2):107-11.
PMID: 22613493
Study sites: Morocco: Casablanca, Fez, Marrakech, Rabat
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:
  • Saber Boutayeb, Oncology Centres of Casablanca
  • Karima Bendahhou, Oncology Centres of Rabat
  • Khalid Hassouni, Oncology Centres of Fez
  • Rhislane Belbaraka, Oncology Centres of Marrakech
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Start date: 2016
Closure date:Ongoing
Objectives:
  • To document cancer site and stage at diagnosis for all patients registered at four oncology centres for a period of 1 month
  • To document time intervals in the care pathway, from symptom onset to the date of initial health-care contact, date of final diagnosis, and date of beginning of treatment
  • To assess how sociocultural and economic factors, accessibility of the oncology centre, beliefs, perceived risks, and health-care provider–related factors influence stage at diagnosis and delays over the cancer path
  • To document the barriers to reaching cancer treatment facilities, through group discussions with cancer patients and health-care providers
Methodology:The basis of the study is a face-to-face qualitative questionnaire survey.
Funding: Lalla Salma Foundation for Cancer Prevention and Treatment
Study sites: Ministry of Health, Morocco
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:
  • Dr Abousselham, Population, Ministry of Health
  • Dr Belakhel, Epidemiology and Disease Control, Ministry of Health
  • Dr Chami, Lalla Salma Foundation for Cancer Prevention and Treatment
  • Dr Lardi, United Nations Population Fund (UNFPA)
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Start date: 2014
Closure date:Ongoing
Objectives: To provide technical support to improve the current information system for monitoring the breast and cervical cancer screening programme
Methodology:We propose for the Breast and Cervical Cancer Early Detection Programme
  • to standardize data collection,
  • to facilitate the tracking of women,
  • to identify screening defaulters, and
  • to generate quality control indicators.
Funding: United Nations Population Fund (UNFPA) Morocco
Study sites: Low- and middle-income countries
Principal investigator (PI) from IARC: R. Sankaranarayanan
Start date: 2014
Closure date:2016
Objectives: To establish an observational prospective cohort of women receiving cervical cancer screening in selected countries implementing cervical cancer screening programmes in order to estimate key process and outcome indicators not currently measurable through routine information systems, and also to validate the tools for data collection
Methodology:
  • A cohort of participants in the existing cervical cancer screening programme was actively followed-up until they underwent the second round of screening, so that key indicators could be measured: screen positivity rate, treatment through single-visit approach (where applicable), compliance with referral, treatment rate (overall), compliance with repeat screening, cervical cancer detection rate, treatment failure rate, failure rate of the screen-and-treat approach (where applicable), and success rate of the screen-and-treat approach (where applicable).
  • Establishment of the observational cohort enabled the implementation of a questionnaire survey on the screen-positive women who did not comply with recommended treatment or referral, to assess the reasons for non-compliance with treatment and referral.
Funding: CDC Foundation, USA
Study sites:
  • Hong Kong Cancer Registry, Hong Kong SAR, China
  • Qidong Cancer Registry, Qidong, China
  • Shanghai Cancer Registry, Shanghai, China
  • Tianjin Cancer Registry, Tianjin, China
  • Universidad de Costa Rica, Costa Rica
  • Registro Nacional de Cáncer de Cuba, Cuba
  • National Cancer Registry of The Gambia, The Gambia
  • Barshi Cancer Registry, Barshi, India
  • Bhopal Cancer Registry, Bhopal, India
  • Madras Metropolitan Tumour Registry, Chennai, India
  • Natural Background Radiation Registry, Karunagappally, India
  • Mumbai Cancer Registry, Mumbai, India
  • Karachi Cancer Registry, Karachi South District, Pakistan
  • Manila Cancer Registry, Manila, Philippines
  • Rizal Cancer Registry, Rizal, Philippines
  • Busan Cancer Registry, Busan, Republic of Korea
  • Incheon Cancer Registry, Incheon, Republic of Korea
  • Seoul Cancer Registry, Seoul, Republic of Korea
  • King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia
  • Singapore Cancer Registry, Singapore
  • Chiang Mai Tumour Registry, Chiang Mai, Thailand
  • Khon Kaen Provincial Cancer Registry, Khon Kaen, Thailand
  • Lampang Cancer Registry, Lampang, Thailand
  • Songkhla Cancer Registry, Songkhla, Thailand
  • Izmir Cancer Registry, Izmir, Turkey
  • Kampala Cancer Registry, Kampala, Uganda
  • Zimbabwe National Cancer Registry, Harare, Zimbabwe
Principal investigator (PI) from IARC: R. Sankaranarayanan
PIs from collaborating institutions:R. Swaminathan, H. Brenner, B. Ganesh, A. Mathew, M. Hakama, K. Jayant
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Start date: 1990
Closure date:2011
Objectives: The dearth of reliable survival statistics from developing countries was very evident until the mid-1990s. This prompted IARC to undertake a project that facilitated hands-on training and thereby the transfer of knowledge and technology on cancer survival analysis to researchers from the participating population-based cancer registries, which culminated in the publication of the first volume of the IARC Scientific Publication on cancer survival in developing countries in 1998. The present study is the second in the series, with wider geographical coverage, and is based on data from 27 registries in 14 countries in Africa, Asia, the Caribbean, and Central America. The calendar period of registration of incident cases for the present study ranges between 1990 and 2001. Data on 564 606 cases of 1–56 cancer sites from different registries are reported. Data from 11 registries were used to determine survival trends and data from 17 registries for reporting survival by clinical extent of disease. The publication includes chapters on each registry and general chapters on methodology, the database, and an overview. Comparative statistics on cancer survival by participating registry or by cancer site are also available online in the form of tables and graphs (http://survcan.iarc.fr).
Methodology:Population-based cancer survival data (a key indicator for monitoring progress against cancer) are not widely available in low- and middle-income countries. Cancer-specific survival of patients diagnosed in 1990–2001, and followed-up to 2003 in 25 population-based cancer registries from 12 countries in sub-Saharan Africa, Central America, and Asia were analysed by actuarial methods.
Visit the SurvCan website
Publications: Sankaranarayanan R., Swaminathan R. Cancer survival in Africa, Asia, the Caribbean and Central America. Lyon: International Agency for Research on Cancer. IARC Scientific Publication No. 162; 2011.
Visit the book’s IARC Publications page
Sankaranarayanan R., Swaminathan R., Brenner H., Chen K., Chia K.S., Chen J.G., Law S.C., Ahn Y.O., Xiang Y.B., Yeole B.B., Shin H.R., Shanta V., Woo Z.H., Martin N., Sumitsawan Y., Sriplung H., Barboza A.O., Eser S., Nene B.M., Suwanrungruang K., Jayalekshmi P., Dikshit R., Wabinga H., Esteban D.B., Laudico A., Bhurgri Y., Bah E., Al-Hamdan N. Cancer survival in Africa, Asia, and Central America: a population-based study. Lancet Oncol. 2010;11(2):165-73.
PMID: 20005175
Funding:
  • Worldwide Cancer Research, St Andrews, United Kingdom
  • Association pour la Recherche sur le Cancer (ARC), Villejuif, France
  • Bill & Melinda Gates Foundation, Seattle, USA

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