|Study sites:||Thiruvananthapuram (formerly called Trivandrum), Kerala, India|
|Principal investigator (PI) from IARC:||R. Sankaranarayanan|
|PIs from collaborating institutions:||K. Ramadas (PI), S. Thara, Beela Sarah Mathew, Elizabeth Abraham, Gigi Thomas, Jem Prabhakar, Paul Augustine, Ramani Wesley, R. Rejnish Kumar, Regional Cancer Centre (RCC), Thiruvananthapuram, Kerala, India|
|Study outcomes:||In 1996–2004, three rounds of oral visual inspection were provided by trained health workers at 3-year intervals to eligible individuals (aged ≥ 34 years) in the intervention group.|
We reported a 35% decrease in mortality rate among the tobacco users/alcohol consumers of the intervention group compared with the control group. This evidence was used by India’s National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Disease and Stroke (NPCDCS) to support their recommendation of oral visual screening of the population.
|Publications:||Sankaranarayanan R., Ramadas K., Thara S., Muwonge R., Thomas G., Anju G., Mathew B. Long term effect of visual screening on oral cancer incidence and mortality in a randomized trial in Kerala, India. Oral Oncol. 2013;49(4):314-21.|
Ramadas K., Sauvaget C., Thomas G., Fayette J.M., Thara S., Sankaranarayanan R. Effect of tobacco chewing, tobacco smoking and alcohol on all-cause and cancer mortality: a cohort study from Trivandrum, India. Cancer Epidemiol. 2010;34(4):405-12.
Subramanian S., Sankaranarayanan R., Bapat B., Somanathan T., Thomas G., Mathew B., Vinoda J., Ramadas K. Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India. Bull World Health Organ. 2009;87(3):200-6.
Sankaranarayanan R., Ramadas K., Thomas G., Muwonge R., Thara S., Mathew B., Rajan B.; Trivandrum Oral Cancer Screening Study Group. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet. 2005;365(9475):1927-33.
Ramadas K., Sankaranarayanan R., Jacob B.J., Thomas G., Somanathan T., Mahé C., Pandey M., Abraham E., Najeeb S., Mathew B., Parkin D.M., Nair M.K. Interim results from a cluster randomized controlled oral cancer screening trial in Kerala, India. Oral Oncol. 2003 Sep;39(6):580-8.
|Study sites:||India: Ambilikkai, Bangalore, Barshi, Guwahati, Sevagram, Thiruvananthapuram|
|Principal investigator (PI) from IARC:||M. Tommasino|
|PIs from collaborating institutions:|
|Methodology:||This is a multicentre study including recruiting centres in Europe and India. The Screening Group is collaborating with the Indian centres. Approximately 4000–6000 HNC specimens are collected from several Indian centres from rural or urban areas. The specimens include cancers of the hypopharynx, oropharynx, oral cavity, and larynx. Each Indian centre provides approximately 1000–1500 specimens representing the four anatomical sites. Epidemiological and clinical data are also collected when available.|
|Study sites:||Udaipur, India|
|Principal investigator (PI) from IARC:||P. Basu|
|PIs from collaborating institutions:||Manoj Mahajan (PI), Kirti Jain, Nilesh Patira, GBH Memorial Cancer Hospital, Udaipur, India|
|Objectives:||To evaluate the feasibility and acceptability of the model of delivering community health worker (CHW)–driven home-based comprehensive noncommunicable disease (NCD) control services aimed to prevent premature deaths from cardiovascular diseases; stroke; and breast, cervical, and oral cancers in hard-to-reach men and women|
The implementation research has two main components, which will be conducted simultaneously:
|Funding:||American International Health Management Ltd|