A digital manual for the early diagnosis of oral neoplasia
Scleroderma is a chronic disease characterized by excessive deposits of collagen in the skin or other organs. This is an autoimmune disease; however, the exact cause of it is not clear. Infections like cytomegalovirus infection and certain chemical agents (including dental amalgams), certain chemotheraputic agents (like bleomycin and taxanes) have been linked with its occurence. Limited mouth opening, xerostomia, increased dental caries, loosening of teeth and mandibular resorption are more common in these individuals. Oral mucosa appears pale and rigid, and loss of the mobility of tongue can also occur.