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Nutritional deficiency  

Several nutritional deficiencies may result in oral manifestions. Cheilitis, angular fissures, and depapillation of dorsum tongue leading to burning sensations at meal times are seen with riboflavin, niacin, B₆, B₁₂ and iron deficiency. Redness and bleeding can occur with vitamin C deficiency. Red, raw and fissured tongue is seen in folate, niacin, iron, B₆ and B₁₂ deficiencies and pale, atrophic and smooth tongue is associated with iron and folate deficiencies. Magenta-coloured tongue can be seen in patients with riboflavin deficiency.

Image	Caption
	Figure 1: Angular cheilitis right and left commissure. Note the horizontal fissures with erosion in the angle of the mouth.
	Figure 2: Angular cheilitis right and left commissure. Note the horizontal fissures with bleeding in the corners of the mouth.
	Figure 3: Note the diffuse blanching of the left buccal mucosa in this 57–year-old man suffering from iron deficiency anemia.
	Figure 4: Note the diffuse blanching of the hard palate in the same patient suffering from iron deficiency anemia.
	Figure 5: Perioral dermatitis in a patient with nutritional deficiency.