In situ adenocarcinoma of the endocervix : A1 & A2: strong positivity of the glandular neoplastic epithelium. The normal endocervical epithelium is not labelled. There is a sharp transition between the normal and neoplastic epithelium. B1 & B2 : Same lesion with superficial glandular dysplasia with low p16 immuno-reactivity (arrows).