Glossary Definitions

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Schiller test
The Schiller (lugol) iodine test is based on the interaction between iodine and glycogen: the squamous epithelium is uniformly coloured dark-brown, the altered epithelium does not take up iodine, the columnar epithelium does not contain glycogen and therefore there is no uptake of iodine. A colposcopic lesion may take all the nuances between brown-red (normal squamous epithelium) to a more light staining which is due to the glycogen charge. Yellow colour is characteristic for atypical or immature epithelium. This test helps to define the limits between the epithelium and the lesion.

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