Abnormalities of squamous cells The Bethesda System 2001: under this expression are grouped morphologic changes of squamous cells, which differ from changes due to inflammatory and reactive conditions. They are: - Atypical squamous cells (ASC) of undetermined significance (ASC-US) or Atypical squamous cells cannot exclude high grade intraepithelial lesion (ASC-H), - Low-grade squamous intraepithelial lesion (LSIL), - High grade intraepithelial lesion (HSIL), - Squamous cell carcinoma. See also: Bethesda