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Central giant cell lesion is charactersied by a benign, but locally aggressive, osteolytic proliferation with reactive bone formation. The mandible is more commonly involved. This is seen in young adults and is more common in women. Clinically, the lesion is asymptomatic and may appear as a swelling sometimes causing pain and paraesthesia, especially in aggressive lesions. Radiographically it appears as a radiolucent, often multi-loculated lesion. Surgical enucleation is the treatment of choice.

Figure 1: Central giant cell lesion. Well marginated hypodense osteolysis with vestibular cortical destruction, but no cortical thinning. Transversal CT scan, bone window.
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