The core function of the Screening Group (SCR) at IARC is to provide data on the accuracy, reproducibility, efficacy, benefits, harmful effects, and cost-effectiveness of various early detection interventions for breast, cervical, colorectal, and oral cancers, among others, in reducing deaths and improving patients’ quality of life in various settings. These data can then be used to inform and improve the rational use of health-care resources. The Group’s ultimate objective is to guide the development of public health policies for implementing screening in a variety of health-care settings, in particular in low- and middle-income countries (LMICs).

SCR conducts field studies in LMICs to evaluate various early detection methods for breast, cervical, colorectal, and oral cancer control. These initiatives also address the means by which screening services could be scaled up through local public health services. SCR develops various training resources to catalyse and augment capacity building in close collaboration with national institutions and government health services. Through its research programme, SCR generates scientific evidence to support the development of resource-appropriate early detection policies and health systems for the delivery of effective early services. The Cancer Screening in 5 Continents (CanScreen5) project of the Group aims to collect information on characteristics and performance of cancer screening programmes around the world and disseminate such information for informed decision making in cancer screening programmes. For example, the Group significantly contributed also to the evaluation of the safety and efficacy of less than three doses of the HPV vaccine in protecting against cervical cancer.

Visitors and news

CARE4Afrique closing meeting

On January 24th, the closing meeting of the CARE4Afrique project was held virtually with the representatives of Benin, Cameroon, Côte d’Ivoire and Senegal, and the Directors of the Lalla Salma Foundation. Challenges in the project implementation and status in scaling up cervical cancer screening and treatment of precancerous lesions were presented. Two countries already started to provide screen-and-treat services within the country. Key elements were identified for the success of scaling up in Sub-Sahara Africa: dedicated budget, lobbying and community participation, regular training of the providers, approach “screen-and-treat” using VIA and thermal ablation. The launch on February 4th of the CARE4Afrique report on IARC website was announced.

Video: The Atlas of Breast Cancer Early Detection with Dr Susan Cherian

Dr Susan Cherian, Head of the Pathology Department at the Bhabha Atomic Research Centre (BARC) Hospital, Mumbai, India, presents the Atlas of Breast Cancer Early Detection. The Atlas provides a guide to the multi-disciplinary approach for diagnosis of breast cancer, including information relating to the detailed clinical breast examination (CBE), diagnostic imaging, and pathological confirmation for every case described in this learning tool. The examples and images are an invaluable resource for healthcare workers to train them in diagnosis and differentiation of breast lumps. The Atlas also includes imagery of breast cancer screening and post-operative surveillance. View the video.

Video: The Atlas of Breast Cancer Early Detection with Dr Partha Basu

Dr Partha Basu, Head of the Early Detection, Prevention & Infections Branch at the International Agency for Research on Cancer (IARC) presents the Atlas of Breast Cancer Early Detection. In this video, Dr Basu provides an overview of the sections and contents of the Atlas, which includes nearly 1000 freely available annotated images and videos, 186 case studies, and a quiz.
View the video.

Atlas of Breast Cancer Early Detection

The International Agency for Research on Cancer (IARC) is pleased to announce the launch of a new digital atlas, the Atlas of Breast Cancer Early Detection. The atlas is a step-by-step guide to the procedure of clinical breast examination and its interpretation, diagnostic mammography, diagnostic breast ultrasound, image-guided fine-needle aspiration cytology, and core biopsy of the breast.
View the digital atlas.

New release (January) of the CanScreen5 platform with new country data

The CanScreen5 IARC Secretariat, following support of country collaborators and validation by our scientific committee, is happy to announce the availability on the CanScreen5 platform of the following country factsheets: Canada (Nova Scotia province data).
Visit the CanScreen5 website to explore characteristics and performance of cancer screening programmes across the globe in more than 77 countries.

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Scientific papers

Mandrik O., Roitberg F., Lauby-Secretan B., Parak U., Ramadas K., Varenne B., Sankaranarayanan R., Carvalho A.L. Perspective on oral cancer screening: Time for implementation research and beyond. J Cancer Policy. 2023 Jan 2;35:100381.
PMID: 36599217
Singh D., Vignat J., Lorenzoni V., Eslahi M., Ginsburg O., Lauby-Secretan B., Arbyn M., Basu P., Bray F., Vaccarella S. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health. 2023 Feb;11(2):e197-e206.
PMID: 36528031
Joshi S., Anantharaman D., Muwonge R., Bhatla N., Panicker G., Butt J., Rani Reddy Poli U., Malvi S.G., Esmy P.O., Lucas E., Verma Y., Shah A., Zomawia E., Pimple S., Jayant K., Hingmire S., Chiwate A., Divate U., Vashist S., Mishra G., Jadhav R., Siddiqi M., Sankaran S., Pillai Rameshwari Ammal Kannan T., Kartha P., Shastri S.S., Sauvaget C., Radhakrishna Pillai M., Waterboer T., Muller M., Sehr P., Unger E.R., Sankaranarayanan R., Basu P. Evaluation of immune response to single dose of quadrivalent HPV vaccine at 10-year post-vaccination. Vaccine. 2023 Jan 4;41(1):236-245.
PMID: 36446654

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