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Cervical cancer prevention and early detection

Artificial intelligence-assisted decision-making to improve women's participation to cervical cancer screening in Occitanie Region-France (AppDate-You)

Study sites: Occitanie region, France
Principal investigator (PI) from IARC: F. Selmouni
PIs from collaborating institutions:
  • Dr Antoine Kreiche, Regional Cancer Screening Management Center of Occitanie region (CRCDC-OC)
  • Prof. Abdelhak Nassiri, Université de Bretagne Occidentale
Start date: 2021
Closure date:Ongoing
  • Improve participation in cervical cancer screening among socially disadvantaged women who have not been followed up in the Occitanie region
  • Reduce morbidity and social inequalities linked to cervical cancer
Methodology:This is a two-arm cluster randomized-controlled trial within the French organized cervical screening programme among non-responders living in deprived areas in Occitanie Region-France. A cluster is defined by aggregated units for statistical information (IRIS) and which refers to the target size of 2000 inhabitants per basic unit. Only IRIS classified 4 and 5 according to the French version of the European Deprivation Index will be included. The clusters will be stratified by population density, medical density, and environment (urban or rural).The intervention will consist in sending HPV self-sampling kit at home and in providing through multiple mobile channels (SMS messages, web, social media, or mobile apps), a multi-language decision aid designed for women with lower education. Women in the experimental group will be sent screening reminder letters to perform self-sampling for HPV, associated with an access via Chatbot platforms to the tailored decision aid. The active control group will receive the reminder letters with a HPV self-sampling kit. The intervention will be evaluated by comparing the "return" rate of HPV self-samples and the proportion of invited women "well managed" between both groups. Economic evaluation using cost-efficacy analysis of this intervention will also be conducted.
Funding: National Cancer Institute (INCa), France

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