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Adenocarcinoma in situ: sharp transition between normal (+) and neoplastic endocervical epithelium (arrow).
Adenocarcinoma in situ (left) coexisting with normal endocervical epithelium (right).
Adenocarcinoma in situ: substitution of normal endocervical epithelium by neoplastic epithelium at the TZ.
Adenocarcinoma in situ: contrast between a normal gland (left) and a neoplastic gland (right).
Papillary adenocarcinoma in situ.
Papillary adenocarcinoma in situ.
Adenocarcinoma in situ developed in adenosis.
Adenocarcinoma in situ developed in adenosis.
Adenocarcinoma in situ developed in adenosis with a gland in gland formation.
Adenocarcinoma in situ developed in adenosis.
Coexisting adenocarcinoma in situ (arrow) and CIN 3 (star).
Adenocarcinoma in situ: marked cellular abnormalities with typical and atypical mitoses.
HE staining: In situ adenocarcinoma of the endocervix (bottom). Normal endocervical mucosa (top). Immunolabelling anti-p16: heavy staining of the glandular neoplastic epithelium (nuclei and cytoplasm - bottom). The normal epithelium is not labelled (top).
In situ adenocarcinoma of the endocervix : A1 & A2: strong positivity of the glandular neoplastic epithelium. The normal endocervical epithelium is not labelled. There is a sharp transition between the normal and neoplastic epithelium. B1 & B2 : Same lesion with superficial glandular dysplasia with low p16 immuno-reactivity (arrows).
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