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Drawing summarizing the evolution of the transformation zone and the genesis of uterine cervix cancer.
Conization: CIN 1 - condyloma. Lesion situated into the ellipse. Free margins of ectocervix (A,B) and endocervix (C).
CIN 1 (flat condyloma): the epithelium organization is disturbed in the lower third. A large abnormal mitotic figure (arrow).
CIN 1 (flat condyloma): an abnormal mitotic figure (yellow circle), numerous binucleated cells (green circle), superficial parakeratosis (red arrow). Disturbed structural organization of the epithelium in the lower third.
CIN 1 (flat condyloma): abnormal mitotic figure (green circle), numerous binucleated cells (yellow circle), koilocytotic cells (stars), superficial parakeratosis (red arrow).
CIN 1 (flat condyloma): two typical koilocytotic cells (green circles) and marked dermal papillae (arrows).
CIN 1 (flat condyloma): occlusion of a glandular orifice.
CIN 1 (flat condyloma): flat condyloma (A) and normal ectocervical epithelium (B) next to each other.
CIN 1 (flat condyloma): koilocytotic cell changes (koilocytosis), superficial parakeratosis and basal cell hyperplasia.
CIN 1 (flat condyloma): binucleated cells (green circle) and monocellular dyskeratosis (yellow circle).
CIN 1 with mild koilocytosis, disorganization of the lower third of the epithelium and koilocytes in the upper third.
CIN 1 with mild koilocytosis, disorganization of the lower third of the epithelium and koilocytes in the upper third.
CIN 1 with mild koilocytosis, disorganization of the lower third of the epithelium and koilocytes in the upper third.
CIN 1: disturbed epithelial maturation with nuclear abnormalities in the lower third of the epithelium.
CIN 1 (inverted condyloma): budding aspect of the lesion.
CIN 1 (Inverted condyloma): budding aspect of the lesion (glandular involvement).
CIN 1 (Inverted condyloma): budding aspect of the lesion (glandular involvement).
CIN 1 (Inverted condyloma): superficial parakeratosis, mild koilocytosis.
CIN 1 (Inverted condyloma): mild koilocytosis.
CIN 1 (Inverted condyloma): disorganization of the lower third of the epithelium, several binucleated cells, koilocytosis.
CIN 1 or inflammatory atypia? Disturbed epithelial maturation with nuclear abnormalities in the lower third of the epithelium. Heavy exudate with lymphocytes and polymorphs. Local treatment is needed to allow a specific diagnosis.
CIN 1 (Flat condyloma): immunohistochemistry, anti-Mib1 antibody: marked positivity of the nuclei of the koilocytotic cells, and of a few nuclei of normal basal cells. Many positive inflammatory cells in the lamina propria.
CIN 1 (Flat condyloma): in situ hybridization, HPV 16 probe: labelling of the nuclei of numerous superficial cells.
HE staining: CIN 1 and then normal ectocervix. Anti-p16 immunolabelling: moderate staining of the CIN 1. No labelling of the normal tissue.
CIN 1 (flat condyloma): transmission electron microscopy, koilocytotic cell nucleus with numerous intranuclear viral particles.
CIN 1(flat condyloma), transmission electron microscopy, high magnification of the HPV virus.
HPV typing (PCR): specimen 1: consensus sequences GP5-GP6 and MY11-MY09 present. Specimen 2: negative results.
HPV typing (PCR): specimen 1: negative results. Specimen 2: HPV 16 positivity (see glossary).
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