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Cytopathology of the uterine cervix - digital atlas

ASC-US, yes or no?  Rechercher ASC-US, yes or no?

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Parabasal cells with enlarged nuclei. This change is not typical of ASC-US. (obj. 20x)


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Reviewer: A L

Stunned.. not one question on this picture..

Why atrophy and not squamous metaplasia? Seeing how distinguishing squamous metaplasia from atrophy is a common cytologic dilemma. The hallmarks of atrophy are parabasal and basal cells. Atrophic cells are often accompanied by undifferentiated basaloid cells, whereas immature metaplastic cells are often accompanied by intermediate-sized mature metaplastic cells. Check out the single basal cell on the bottom and a few in the middle left. The dirty background points you more towards atrophy, although it is not specific. Atrophic cells tend to dominate the slide, while metaplastic cells are most limited.
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